I keep wanting to say "Zork I," but I think it might actually have been beaten by one of the old Scott Adams adventures, "Questprobe: Spider-Man," for the C-64. It's incredibly weird, and except for the fact that you occasionally run into Spider-Man villains, it has about as much to do with Spider-Man as bread has to do with sheep (as in, you might be able to find a connection, but you'd be looking pretty dang hard trying to find it). You spend the entire game running around a high-rise, looking for hidden gems to give to "famous" Spider-Man character Madame Web (told you it was weird), and the puzzle solutions, in order to avoid the non-violence that permeated Scott Adams adventures, were increasingly bizarre. To get rid of one NPC, you had to close your eyes, walk into the room where he was, and fiddle with a knob on the wall until he leaves. No explanation why.
At least it's more sensible than the earlier Scott Adams "Hulk" game. That one has you lifting bio-domes looking for gems, giant ants trying to eat your eyes, and having to eat and swallow a radioactive "egg bomb" before gas turns you back into Bruce Banner.
Scott Adams was kind of strange, wasn't he?